Ontology highlight
ABSTRACT:
SUBMITTER: Desbiens L
PROVIDER: S-EPMC5005578 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Desbiens Louisane L Lapointe Catherine C Gharagozloo Marjan M Mahmoud Shaimaa S Pejler Gunnar G Gris Denis D D'Orléans-Juste Pedro P
Mediators of inflammation 20160817
Experimental autoimmune encephalomyelitis (EAE) is a mouse model that reproduces cardinal signs of clinical, histopathological, and immunological features found in Multiple Sclerosis (MS). Mast cells are suggested to be involved in the main inflammatory phases occurring during EAE development, possibly by secreting several autacoids and proteases. Among the latter, the chymase mouse mast cell protease 4 (mMCP-4) can contribute to the inflammatory response by producing endothelin-1 (ET-1). The ai ...[more]