Ontology highlight
ABSTRACT:
SUBMITTER: Martin-Guerrero I
PROVIDER: S-EPMC5005837 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Martin-Guerrero Idoia I de Prado Elena E Ardanaz Maite M Martin-Arruti Maialen M Garcia-Orad Cristina C Guerra Isabel I Ruiz Irune I Zabalza Iñaki I Garcia-Orad Africa A
Age (Dordrecht, Netherlands) 20150903 5
The BCL2 breakage mechanism has been shown to be highly dependent on DNA methylation at the major breakpoint region (MBR) CpG sites. We recently described an increased frequency of BCL2/ JH translocation with aging. It is known that methylation levels change with aging. The present study aimed to determine whether methylation alterations at CpG sites of BCL2 MBR were the cause of increased breakages with aging. We analyzed the methylation levels of three CpG sites on the region by pyrosequencing ...[more]