Unknown

Dataset Information

0

A toxin antitoxin system promotes the maintenance of the IncA/C-mobilizable Salmonella Genomic Island 1.


ABSTRACT: The multidrug resistance Salmonella Genomic Island 1 (SGI1) is an integrative mobilizable element identified in several enterobacterial pathogens. This chromosomal island requires a conjugative IncA/C plasmid to be excised as a circular extrachromosomal form and conjugally mobilized in trans. Preliminary observations suggest stable maintenance of SGI1 in the host chromosome but paradoxically also incompatibility between SGI1 and IncA/C plasmids. Here, using a Salmonella enterica serovar Agona clonal bacterial population as model, we demonstrate that a Toxin-Antitoxin (TA) system encoded by SGI1 plays a critical role in its stable host maintenance when an IncA/C plasmid is concomitantly present. This system, designated sgiAT for Salmonella genomic island 1 Antitoxin and Toxin respectively, thus seems to play a stabilizing role in a situation where SGI1 is susceptible to be lost through plasmid IncA/C-mediated excision. Moreover and for the first time, the incompatibility between SGI1 and IncA/C plasmids was experimentally confirmed.

SUBMITTER: Huguet KT 

PROVIDER: S-EPMC5006074 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

A toxin antitoxin system promotes the maintenance of the IncA/C-mobilizable Salmonella Genomic Island 1.

Huguet Kevin T KT   Gonnet Mathieu M   Doublet Benoît B   Cloeckaert Axel A  

Scientific reports 20160831


The multidrug resistance Salmonella Genomic Island 1 (SGI1) is an integrative mobilizable element identified in several enterobacterial pathogens. This chromosomal island requires a conjugative IncA/C plasmid to be excised as a circular extrachromosomal form and conjugally mobilized in trans. Preliminary observations suggest stable maintenance of SGI1 in the host chromosome but paradoxically also incompatibility between SGI1 and IncA/C plasmids. Here, using a Salmonella enterica serovar Agona cl  ...[more]

Similar Datasets

| S-EPMC8265657 | biostudies-literature
| S-EPMC3868539 | biostudies-literature
| S-EPMC2297512 | biostudies-literature
2021-07-05 | PXD023449 | Pride
| S-EPMC8409611 | biostudies-literature
| S-EPMC3004903 | biostudies-literature
2020-02-06 | PXD015525 | Pride
| S-EPMC5155140 | biostudies-literature
| S-EPMC4926146 | biostudies-literature
| S-EPMC3514572 | biostudies-literature