Whole-exome sequencing reveals genetic variability among lung cancer cases subphenotyped for emphysema.
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ABSTRACT:
SUBMITTER: Lusk CM
PROVIDER: S-EPMC5006210 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
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Whole-exome sequencing reveals genetic variability among lung cancer cases subphenotyped for emphysema.
Lusk Christine M CM Wenzlaff Angela S AS Dyson Greg G Purrington Kristen S KS Watza Donovan D Land Susan S Soubani Ayman O AO Gadgeel Shirish M SM Schwartz Ann G AG
Carcinogenesis 20151230 2
Lung cancer continues to be a major public health challenge in the United States despite efforts to decrease the prevalence of smoking; outcomes are especially poor for African-American patients compared to other races/ethnicities. Chronic obstructive pulmonary disease (COPD) co-occurs with lung cancer frequently, but not always, suggesting both shared and distinct risk factors for these two diseases. To identify germline genetic variation that distinguishes between lung cancer in the presence a ...[more]
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