Ontology highlight
ABSTRACT:
SUBMITTER: Deshpande S
PROVIDER: S-EPMC5006590 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Retrovirology 20160830 1
The glycan supersite centered on N332 in the V3 base of the HIV-1 envelope (Env) is a target for broadly neutralizing antibodies (bnAbs) such as PGT121 and PGT128. In this study, we examined the basis of resistance of HIV-1 clade C Envs obtained from broadly cross neutralizing (BCN) plasma of an Indian donor with N332 specificity. Pseudotyped viruses expressing autologous envs were found to be resistant to autologous BCN plasma as well as to PGT121 and PGT128 mAbs despite the majority of Envs co ...[more]