Ontology highlight
ABSTRACT:
SUBMITTER: Jurado KA
PROVIDER: S-EPMC5007065 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Jurado Kellie Ann KA Simoni Michael K MK Tang Zhonghua Z Uraki Ryuta R Hwang Jesse J Householder Sarah S Wu Mingjie M Lindenbach Brett D BD Abrahams Vikki M VM Guller Seth S Fikrig Erol E
JCI insight 20160801 13
The strong association of Zika virus infection with congenital defects has led to questions of how a flavivirus is capable of crossing the placental barrier to reach the fetal brain. Here, we demonstrate permissive Zika virus infection of primary human placental macrophages, commonly referred to as Hofbauer cells, and placental villous fibroblasts. We also demonstrate Zika virus infection of Hofbauer cells within the context of the tissue ex vivo using term placental villous explants. In additio ...[more]