Ontology highlight
ABSTRACT:
SUBMITTER: McCoy LE
PROVIDER: S-EPMC5007210 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Cell reports 20160818 9
A major advance in the search for an HIV vaccine has been the development of a near-native Envelope trimer (BG505 SOSIP.664) that can induce robust autologous Tier 2 neutralization. Here, potently neutralizing monoclonal antibodies (nAbs) from rabbits immunized with BG505 SOSIP.664 are shown to recognize an immunodominant region of gp120 centered on residue 241. Residue 241 occupies a hole in the glycan defenses of the BG505 isolate, with fewer than 3% of global isolates lacking a glycan site at ...[more]