Ontology highlight
ABSTRACT:
SUBMITTER: Shen X
PROVIDER: S-EPMC5007516 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Shen Xiujin X Jiang Hong H Ying Meike M Xie Zhoutao Z Li Xiayu X Wang Haibing H Zhao Jie J Lin Chuan C Wang Yucheng Y Feng Shi S Shen Jia J Weng Chunhua C Lin Weiqiang W Wang Huiping H Zhou Qin Q Bi Yan Y Li Meng M Wang Lingyan L Zhu Tongyu T Huang Xiaoru X Lan Hui-Yao HY Zhou Jing J Chen Jianghua J
Scientific reports 20160901
Podocyte injury and the appearance of proteinuria are features of minimal-change disease (MCD). Cyclosporin A (CsA) and tacrolimus (FK506) has been reported to reduce proteinuria in patients with nephrotic syndrome, but mechanisms remain unknown. We, therefore, investigated the protective mechanisms of CsA and FK506 on proteinuria in a rat model of MCD induced by puromycin aminonucleoside (PAN) and in vitro cultured mouse podocytes. Our results showed that CsA and FK506 treatment decreased prote ...[more]