Ontology highlight
ABSTRACT:
SUBMITTER: Bennett A
PROVIDER: S-EPMC5008013 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Bennett Ailsa A Sloss Olivia O Topham Caroline C Nelson Louisa L Tighe Anthony A Taylor Stephen S SS
Open biology 20160801 8
Cell fate in response to an aberrant mitosis is governed by two competing networks: the spindle assembly checkpoint (SAC) and the intrinsic apoptosis pathway. The mechanistic interplay between these two networks is obscured by functional redundancy and the ability of cells to die either in mitosis or in the subsequent interphase. By coupling time-lapse microscopy with selective pharmacological agents, we systematically probe pro-survival Bcl-xL in response to various mitotic perturbations. Conce ...[more]