Ontology highlight
ABSTRACT:
SUBMITTER: Hirvinen M
PROVIDER: S-EPMC5008257 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Hirvinen Mari M Capasso Cristian C Guse Kilian K Garofalo Mariangela M Vitale Andrea A Ahonen Marko M Kuryk Lukasz L Vähä-Koskela Markus M Hemminki Akseli A Fortino Vittorio V Greco Dario D Cerullo Vincenzo V
Molecular therapy oncolytics 20160323
In oncolytic virotherapy, the ability of the virus to activate the immune system is a key attribute with regard to long-term antitumor effects. Vaccinia viruses bear one of the strongest oncolytic activities among all oncolytic viruses. However, its capacity for stimulation of antitumor immunity is not optimal, mainly due to its immunosuppressive nature. To overcome this problem, we developed an oncolytic VV that expresses intracellular pattern recognition receptor DNA-dependent activator of IFN ...[more]