Ontology highlight
ABSTRACT:
SUBMITTER: Yi JK
PROVIDER: S-EPMC5008273 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Yi Jae Kyo JK Xu Ruijuan R Jeong Eunmi E Mileva Izolda I Truman Jean-Philip JP Lin Chih-Li CL Wang Kai K Snider Justin J Wen Sally S Obeid Lina M LM Hannun Yusuf A YA Mao Cungui C
Oncotarget 20160401 16
Sphingoid bases (SBs) as bioactive sphingolipids, have been implicated in aging in yeast. However, we know neither how SBs are regulated during yeast aging nor how they, in turn, regulate it. Herein, we demonstrate that the yeast alkaline ceramidases (YPC1 and YDC1) and SB kinases (LCB4 and LCB5) cooperate in regulating SBs during the aging process and that SBs shortens chronological life span (CLS) by compromising mitochondrial functions. With a lipidomics approach, we found that SBs were incre ...[more]