Ontology highlight
ABSTRACT:
SUBMITTER: Takam Kamga P
PROVIDER: S-EPMC5008317 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Takam Kamga Paul P Bassi Giulio G Cassaro Adriana A Midolo Martina M Di Trapani Mariano M Gatti Alessandro A Carusone Roberta R Resci Federica F Perbellini Omar O Gottardi Michele M Bonifacio Massimiliano M Nwabo Kamdje Armel Hervé AH Ambrosetti Achille A Krampera Mauro M
Oncotarget 20160401 16
Both preclinical and clinical investigations suggest that Notch signalling is critical for the development of many cancers and for their response to chemotherapy. We previously showed that Notch inhibition abrogates stromal-induced chemoresistance in lymphoid neoplasms. However, the role of Notch in acute myeloid leukemia (AML) and its contribution to the crosstalk between leukemia cells and bone marrow stromal cells remain controversial. Thus, we evaluated the role of the Notch pathway in the p ...[more]