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Network pharmacology dissection of multiscale mechanisms of herbal medicines in stage IV gastric adenocarcinoma treatment.

ABSTRACT: Increasing evidence has shown that Chinese Herbal Medicine (CHM) has efficient therapeutic effects for advanced gastric adenocarcinoma, while the therapeutic mechanisms underlying this treatment remain unclear.In this study, the Kaplan-Meier method and Cox regression analysis were used to evaluate the survival benefit of CHM treatment, and correlation analysis was applied to identify the most effective components in the formulas. A network pharmacological approach was developed to decipher the potential therapeutic mechanisms of CHM.CHM treatment was an independent protective factor. The hazard ratio was 0.364 (95% CI 0.245-0.540; P?

SUBMITTER: Gao L

PROVIDER: S-EPMC5008533 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Network pharmacology dissection of multiscale mechanisms of herbal medicines in stage IV gastric adenocarcinoma treatment.

Gao Li L Hao Jian J Niu Yang-Yang YY Tian Miao M Yang Xue X Zhu Cui-Hong CH Ding Xiu-Li XL Liu Xiao-Hui XH Zhang Hao-Ran HR Liu Chang C Qin Xue-Mei XM Wu Xiong-Zhi XZ

Medicine 20160801 35

Increasing evidence has shown that Chinese Herbal Medicine (CHM) has efficient therapeutic effects for advanced gastric adenocarcinoma, while the therapeutic mechanisms underlying this treatment remain unclear.In this study, the Kaplan-Meier method and Cox regression analysis were used to evaluate the survival benefit of CHM treatment, and correlation analysis was applied to identify the most effective components in the formulas. A network pharmacological approach was developed to decipher the p ...[more]

PMID: 27583849

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