Body mass index, serum total cholesterol, and risk of gastric high-grade dysplasia: A case-control study among Chinese adults.

ABSTRACT: Obesity is related to an increased risk of gastric cardia cancer. However, the influences of excess body weight and serum total cholesterol on the risk of gastric high-grade dysplasia have not been fully characterized.A case-control study was conducted to explore the relationships between body mass index (BMI), serum total cholesterol level, and the risk of gastric high-grade dysplasia in Chinese adults. A total of 893 consecutive patients with gastric high-grade dysplasia (537 men and 356 women) and 902 controls (543 men and 359 women) were enrolled from January 2000 to October 2015. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated, and a multivariate analysis was conducted.After adjusting for age, alcohol consumption, smoking status, family history of gastric cancer or esophageal cancer, and serum total cholesterol level, a BMI ranging from 27.5 to 29.9 was significantly related to an increased risk of gastric high-grade dysplasia in both men (adjusted OR?=?1.87, 95% CI?=?1.24-2.81) and women (adjusted OR?=?2.72, 95% CI?=?1.44-5.16). The 2 highest BMI categories (27.5-29.9 and ?30.0) were identified as risk factors for gastric cardia high-grade dysplasia in both men (BMI?=?27.5-29.9: adjusted OR?=?1.78, 95% CI?=?1.02-3.10; BMI ? 30.0: adjusted OR?=?2.54, 95% CI?=?1.27-5.08) and women (BMI?=?27.5-29.9: adjusted OR?=?2.88, 95% CI?=?1.27-6.55; BMI ? 30.0: adjusted OR?=?2.77, 95% CI?=?1.36-5.64), whereas only a BMI ranging from 27.5 to 29.9 was a risk factor for gastric noncardia high-grade dysplasia in both men (adjusted OR?=?1.98, 95% CI?=?1.25-3.14) and women (adjusted OR?=?2.88, 95% CI?=?1.43-5.81). In addition, higher serum total cholesterol was associated with an increased risk of gastric noncardia high-grade dysplasia (adjusted OR?=?1.83, 95% CI?=?1.25-2.69) in women.Increased BMI was associated with an increased risk of gastric high-grade dysplasia in both men and women, and higher serum total cholesterol increased the risk of gastric noncardia high-grade dysplasia in women.

SUBMITTER: Huang YK 

PROVIDER: S-EPMC5008598 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature