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The CYP19A1 rs3751592 variant confers susceptibility to Alzheimer disease in the Chinese Han population.

ABSTRACT: The CYP19A1 enzyme (aromatase) encoded by the cytochrome P450 (CYP) 19A1 gene influences the final step in the biosynthesis of estrogen, which has been associated with Alzheimer disease (AD). It is possible that genetic polymorphisms in CYP19A1 could influence the risk of AD by altering the expression of CYP19A1. The ?4 allele of the apolipoprotein E (APOE) gene, which is the most significant known genetic risk factor for AD, may mask the effects of other loci.To assess the potential association of CYP19A1 gene polymorphisms with the risk of AD, we conducted a case-control study in a Chinese Han population by recruiting 463 cases, including 207 patients diagnosed with AD and 256 healthy people matched for sex and age.In APOE ?4 carriers, the distributions of the G allele and the AG?+?GG genotype of CYP19A1 rs3751592 in patients differed significantly (P?

SUBMITTER: Zheng J

PROVIDER: S-EPMC5008603 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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The CYP19A1 rs3751592 variant confers susceptibility to Alzheimer disease in the Chinese Han population.

Zheng Jiaqiang J Yan Huacheng H Shi Lei L Kong Yanying Y Zhao Yongpan Y Xie Li L Li Jian J Huang Mukun M Li Jin J Zhao Shujin S

Medicine 20160801 35

<h4>Background</h4>The CYP19A1 enzyme (aromatase) encoded by the cytochrome P450 (CYP) 19A1 gene influences the final step in the biosynthesis of estrogen, which has been associated with Alzheimer disease (AD). It is possible that genetic polymorphisms in CYP19A1 could influence the risk of AD by altering the expression of CYP19A1. The ε4 allele of the apolipoprotein E (APOE) gene, which is the most significant known genetic risk factor for AD, may mask the effects of other loci.<h4>Methods</h4> ...[more]

PMID: 27583919

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