Novel therapies for myelofibrosis.
Ontology highlight
ABSTRACT:
SUBMITTER: Stein BL
PROVIDER: S-EPMC5008691 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Novel therapies for myelofibrosis.
Stein Brady L BL Cervantes Francisco F Giles Francis F Harrison Claire N CN Verstovsek Srdan S
Leukemia & lymphoma 20150518 10
Myelofibrosis (MF), including primary, post-essential thrombocythemia and post-polycythemia vera MF, associates with a reduced quality of life and shortened life expectancy. Dysregulation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is prominent, even in the absence of the JAK2(V617F) mutation. Therefore, all symptomatic MF patients may potentially derive benefit from JAK inhibitors. Despite the efficacy of JAK inhibitors in controlling signs and symp ...[more]
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