Rapid Inflammation in Mice Lacking Both SOCS1 and SOCS3 in Hematopoietic Cells.
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ABSTRACT:
SUBMITTER: Ushiki T
PROVIDER: S-EPMC5008821 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Rapid Inflammation in Mice Lacking Both SOCS1 and SOCS3 in Hematopoietic Cells.
Ushiki Takashi T Huntington Nicholas D ND Glaser Stefan P SP Kiu Hiu H Georgiou Angela A Zhang Jian-Guo JG Metcalf Donald D Nicola Nicos A NA Roberts Andrew W AW Alexander Warren S WS
PloS one 20160901 9
The Suppressors of Cytokine Signalling (SOCS) proteins are negative regulators of cytokine signalling required to prevent excess cellular responses. SOCS1 and SOCS3 are essential to prevent inflammatory disease, SOCS1 by attenuating responses to IFNγ and gamma-common (γc) cytokines, and SOCS3 via regulation of G-CSF and IL-6 signalling. SOCS1 and SOCS3 show significant sequence homology and are the only SOCS proteins to possess a KIR domain. The possibility of overlapping or redundant functions ...[more]
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