Ontology highlight
ABSTRACT:
SUBMITTER: de Denus S
PROVIDER: S-EPMC5009007 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
de Denus S S Rouleau J L JL Mann D L DL Huggins G S GS Cappola T P TP Shah S H SH Keleti J J Zada Y F YF Provost S S Bardhadi A A Phillips M S MS Normand V V Mongrain I I Dubé M-P MP
The pharmacogenomics journal 20160301 2
We conducted a meta-analysis of pharmacogenomic substudies of three randomized trials conducted in patients with decompensated heart failure (HF) that were led by National Heart Lung and Blood Institute (NHLBI)-funded HF Network to test the hypothesis that candidate genes modulate net fluid loss and weight change in patients with decompensated HF treated with a furosemide-based diuretic regimen. Although none of the genetic variants previously shown to modulate the effects of loop diuretics in h ...[more]