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Ideal glycated hemoglobin cut-off points for screening diabetes and prediabetes in a Chinese population.

ABSTRACT: AIMS/INTRODUCTION:The aims of the present study were to evaluate the diagnostic value of fasting plasma glucose, 2-h postload plasma glucose and glycosylated hemoglobin (HbA1c) measurements in the screening of diabetes and prediabetes, and to determine the cut-off point of HbA1c in the diagnosis of diabetes and prediabetes in a Chinese population. MATERIALS AND METHODS:A total of 7,611 individuals aged 40 years or older, who did not have a prior history of diabetes, were randomly selected in the Changchun area. For each participant, a questionnaire was completed, and a physical examination and an oral glucose tolerance test were carried out. The values of fasting plasma glucose, 2-h postload plasma glucose and HbA1c were compared by area under the receiver operating characteristic curves. The Youden index was used to identify the optimal cut-off point of HbA1c in the diagnosis of diabetes and prediabetes. RESULTS:The prevalence of newly diagnosed diabetes and prediabetes was 12.71% and 29.39%, respectively. In participants with newly diagnosed diabetes, the area under the receiver operating characteristic curve was 0.8368 for fasting plasma glucose, 0.9330 for 2-h postload plasma glucose and 0.8064 for HbA1c; whereas for prediabetes, these values were 0.8022, 0.9288 and 0.6895, respectively. In addition, an HbA1c threshold of 6.3% showed the highest Youden index (0.4799) for detecting diabetes; furthermore, an HbA1c threshold of 5.8% showed the highest Youden index (0.2866) for detecting prediabetes. CONCLUSIONS:HbA1c ?6.3% (45 mmol/mol) and between 5.8% and 6.2% (40-44 mmol/mol) were the optimal cut-off values for the diagnosis of diabetes and prediabetes, respectively, in a Chinese population.

SUBMITTER: Liu Y

PROVIDER: S-EPMC5009131 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Ideal glycated hemoglobin cut-off points for screening diabetes and prediabetes in a Chinese population.

Liu Yujia Y Xiao Xianchao X Sun Chenglin C Tian Suyan S Sun Zhonghua Z Gao Ying Y Li Yazhen Y Cheng Jie J Lv You Y Li Mei M Li Zhuo Z Zhang Yumin Y Wang Gang G Liu Yang Y Gao Yuan Y Zhu Liwen L Liu Yan Y Wang Guixia G

Journal of diabetes investigation 20160503 5

<h4>Aims/introduction</h4>The aims of the present study were to evaluate the diagnostic value of fasting plasma glucose, 2-h postload plasma glucose and glycosylated hemoglobin (HbA1c) measurements in the screening of diabetes and prediabetes, and to determine the cut-off point of HbA1c in the diagnosis of diabetes and prediabetes in a Chinese population.<h4>Materials and methods</h4>A total of 7,611 individuals aged 40 years or older, who did not have a prior history of diabetes, were randomly ...[more]

PMID: 27181567

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Dataset Information

Ideal glycated hemoglobin cut-off points for screening diabetes and prediabetes in a Chinese population.

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Ideal glycated hemoglobin cut-off points for screening diabetes and prediabetes in a Chinese population.

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