Ontology highlight
ABSTRACT:
SUBMITTER: Morhayim J
PROVIDER: S-EPMC5009378 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Morhayim Jess J van de Peppel Jeroen J Braakman Eric E Rombouts Elwin W J C EW Ter Borg Mariette N D MN Dudakovic Amel A Chiba Hideki H van der Eerden Bram C J BC Raaijmakers Marc H MH van Wijnen Andre J AJ Cornelissen Jan J JJ van Leeuwen Johannes P JP
Scientific reports 20160902
Osteolineage cells represent one of the critical bone marrow niche components that support maintenance of hematopoietic stem and progenitor cells (HSPCs). Recent studies demonstrate that extracellular vesicles (EVs) regulate stem cell development via horizontal transfer of bioactive cargo, including microRNAs (miRNAs). Using next-generation sequencing we show that human osteoblast-derived EVs contain highly abundant miRNAs specifically enriched in EVs, including critical regulators of hematopoie ...[more]