Detection of Drug-Induced Acute Kidney Injury in Humans Using Urinary KIM-1, miR-21, -200c, and -423.
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ABSTRACT:
SUBMITTER: Pavkovic M
PROVIDER: S-EPMC5009468 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Publications
Detection of Drug-Induced Acute Kidney Injury in Humans Using Urinary KIM-1, miR-21, -200c, and -423.
Pavkovic Mira M Robinson-Cohen Cassianne C Chua Alicia S AS Nicoara Oana O Cárdenas-González Mariana M Bijol Vanesa V Ramachandran Krithika K Hampson Lucy L Pirmohamed Munir M Antoine Daniel J DJ Frendl Gyorgy G Himmelfarb Jonathan J Waikar Sushrut S SS Vaidya Vishal S VS
Toxicological sciences : an official journal of the Society of Toxicology 20160427 1
Drug-induced acute kidney injury (AKI) is often encountered in hospitalized patients. Although serum creatinine (SCr) is still routinely used for assessing AKI, it is known to be insensitive and nonspecific. Therefore, our objective was to evaluate kidney injury molecule 1 (KIM-1) in conjunction with microRNA (miR)-21, -200c, and -423 as urinary biomarkers for drug-induced AKI in humans. In a cross-sectional cohort of patients (n = 135) with acetaminophen (APAP) overdose, all 4 biomarkers were s ...[more]
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