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Soluble ST2 and Galectin-3: What We Know and Don't Know Analytically.

ABSTRACT: The proteins soluble ST2 (sST2) and galectin-3 are currently gaining mounting interest as candidate biomarkers in cardiac disease. Both, sST2 and galectin-3 have been included in the 2013 ACCF/AHA guideline for additive risk stratification of patients with acute and chronic heart failure. The aim of this review is to provide information on analytical considerations of measuring circulating sST2 and galectin-3 including knowledge on in vitro stability, biological variation and reference ranges of both analytes.

SUBMITTER: Mueller T 

PROVIDER: S-EPMC5009947 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Soluble ST2 and Galectin-3: What We Know and Don't Know Analytically.

Mueller Thomas T   Dieplinger Benjamin B  

EJIFCC 20160801 3

The proteins soluble ST2 (sST2) and galectin-3 are currently gaining mounting interest as candidate biomarkers in cardiac disease. Both, sST2 and galectin-3 have been included in the 2013 ACCF/AHA guideline for additive risk stratification of patients with acute and chronic heart failure. The aim of this review is to provide information on analytical considerations of measuring circulating sST2 and galectin-3 including knowledge on in vitro stability, biological variation and reference ranges of  ...[more]

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