Ontology highlight
ABSTRACT:
SUBMITTER: Cowardin CA
PROVIDER: S-EPMC5010011 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Nature microbiology 20160711 8
Clostridium difficile is the most common hospital acquired pathogen in the USA, and infection is, in many cases, fatal. Toxins A and B are its major virulence factors, but expression of a third toxin, known as C. difficile transferase (CDT), is increasingly common. An adenosine diphosphate (ADP)-ribosyltransferase that causes actin cytoskeletal disruption, CDT is typically produced by the major, hypervirulent strains and has been associated with more severe disease. Here, we show that CDT enhanc ...[more]