Ontology highlight
ABSTRACT:
SUBMITTER: Corrado M
PROVIDER: S-EPMC5010050 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Corrado Mauro M Mariotti Francesca R FR Trapani Laura L Taraborrelli Lucia L Nazio Francesca F Cianfanelli Valentina V Soriano Maria Eugenia ME Schrepfer Emilie E Cecconi Francesco F Scorrano Luca L Campello Silvia S
The EMBO journal 20160707 16
Mitochondrial dynamics and functionality are linked to the autophagic degradative pathway under several stress conditions. However, the interplay between mitochondria and autophagy upon cell death signalling remains unclear. The T-cell receptor pathway signals the so-called activation-induced cell death (AICD) essential for immune tolerance regulation. Here, we show that this apoptotic pathway requires the inhibition of macroautophagy. Protein kinase-A activation downstream of T-cell receptor si ...[more]