Ontology highlight
ABSTRACT:
SUBMITTER: Levin M
PROVIDER: S-EPMC5010428 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Levin Mattias M King Jasmine J JJ Glanville Jacob J Jackson Katherine J L KJ Looney Timothy J TJ Hoh Ramona A RA Mari Adriano A Andersson Morgan M Greiff Lennart L Fire Andrew Z AZ Boyd Scott D SD Ohlin Mats M
The Journal of allergy and clinical immunology 20151111 5
<h4>Background</h4>Specific immunotherapy (SIT) is the only treatment with proved long-term curative potential in patients with allergic disease. Allergen-specific IgE is the causative agent of allergic disease, and antibodies contribute to SIT, but the effects of SIT on aeroallergen-specific B-cell repertoires are not well understood.<h4>Objective</h4>We sought to characterize the IgE sequences expressed by allergen-specific B cells and track the fate of these B-cell clones during SIT.<h4>Metho ...[more]