Scanning thin-sheet laser imaging microscopy elucidates details on mouse ear development.

ABSTRACT:

Background

The mammalian inner ear is transformed from a flat placode into a three-dimensional (3D) structure with six sensory epithelia that allow for the perception of sound and both linear and angular acceleration. While hearing and balance problems are typically considered to be adult onset diseases, they may arise as a developmental perturbation to the developing ear. Future prevention of hearing or balance loss requires an understanding of how closely genetic mutations in model organisms reflect the human case, necessitating an objective multidimensional comparison of mouse ears with human ears that have comparable mutations in the same gene.

Results

Here, we present improved 3D analyses of normal murine ears during embryonic development using optical sections obtained

SUBMITTER: Kopecky B 

PROVIDER: S-EPMC5010664 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature