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Second-generation inhibitors of Bruton tyrosine kinase.

ABSTRACT: Bruton tyrosine kinase (BTK) is a critical effector molecule for B cell development and plays a major role in lymphoma genesis. Ibrutinib is the first-generation BTK inhibitor. Ibrutinib has off-target effects on EGFR, ITK, and Tec family kinases, which explains the untoward effects of ibrutinib. Resistance to ibrutinib was also reported. The C481S mutation in the BTK kinase domain was reported to be a major mechanism of resistance to ibrutinib. This review summarizes the clinical development of novel BTK inhibitors, ACP-196 (acalabrutinib), ONO/GS-4059, and BGB-3111.

SUBMITTER: Wu J

PROVIDER: S-EPMC5010774 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Second-generation inhibitors of Bruton tyrosine kinase.

Wu Jingjing J Liu Christina C Tsui Stella T ST Liu Delong D

Journal of hematology & oncology 20160902 1

Bruton tyrosine kinase (BTK) is a critical effector molecule for B cell development and plays a major role in lymphoma genesis. Ibrutinib is the first-generation BTK inhibitor. Ibrutinib has off-target effects on EGFR, ITK, and Tec family kinases, which explains the untoward effects of ibrutinib. Resistance to ibrutinib was also reported. The C481S mutation in the BTK kinase domain was reported to be a major mechanism of resistance to ibrutinib. This review summarizes the clinical development of ...[more]

PMID: 27590878

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