Ontology highlight
ABSTRACT:
SUBMITTER: Knudsen ES
PROVIDER: S-EPMC5010785 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Knudsen Erik S ES O'Reilly Eileen M EM Brody Jonathan R JR Witkiewicz Agnieszka K AK
Gastroenterology 20150915 1
Patients with pancreatic ductal adenocarcinoma (PDA) have a poor prognosis despite new treatments; approximately 7% survive for 5 years. Although there have been advances in systemic, primarily cytotoxic, therapies, it has been a challenge to treat patients with PDA using targeted therapies. Sequence analyses have provided a wealth of information about the genetic features of PDA and have identified potential therapeutic targets. Preclinical and early-phase clinical studies have found specific p ...[more]