Ontology highlight
ABSTRACT:
SUBMITTER: Erick TK
PROVIDER: S-EPMC5010994 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Erick Timothy K TK Anderson Courtney K CK Reilly Emma C EC Wands Jack R JR Brossay Laurent L
Journal of immunology (Baltimore, Md. : 1950) 20160812 6
The submandibular salivary gland (SMG), a major site of persistent infection for many viruses, contains a large NK cell population. Using NFIL3-deficient mice, PLZF reporter/fate mapping mice, and mixed bone marrow chimeras, we identified two distinct populations of NK cells in the SMG. Although phenotypically unique, the main population relies on NFIL3, but not PLZF, for development and, therefore, is developmentally similar to the conventional NK cell subset. In contrast, we found that approxi ...[more]