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A quantitative trait locus for ascites on chromosome 9 in broiler chicken lines.

ABSTRACT: A genome-wide SNP survey was used to identify chromosomal regions that showed linkage disequilibrium with respect to ascites susceptibility and ventricular hypertrophy in an F2 cross between previously described ascites-resistant and -susceptible lines. Variable number tandem repeats were used to obtain genotype data to further characterize these regions. A region on chromosome 9 (12 to 13 Mbp in 2011 assembly) shows association with ascites in the ascites lines and in several commercial broiler breeder lines with a significant sex effect. There are 2 candidate genes, AGTR1 (an angiotensin II type 1 receptor) and UTS2D (urotensin 2 domain containing), in this region that have been associated with hypertension and hypoxic response in mammals.

SUBMITTER: Krishnamoorthy S

PROVIDER: S-EPMC5011412 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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A quantitative trait locus for ascites on chromosome 9 in broiler chicken lines.

Krishnamoorthy Sriram S Smith Candace D CD Al-Rubaye Adnan A AA Erf Gisela F GF Wideman Robert F RF Anthony Nicholas B NB Rhoads Douglas D DD

Poultry science 20140201 2

A genome-wide SNP survey was used to identify chromosomal regions that showed linkage disequilibrium with respect to ascites susceptibility and ventricular hypertrophy in an F2 cross between previously described ascites-resistant and -susceptible lines. Variable number tandem repeats were used to obtain genotype data to further characterize these regions. A region on chromosome 9 (12 to 13 Mbp in 2011 assembly) shows association with ascites in the ascites lines and in several commercial broiler ...[more]

PMID: 24570451

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