Ontology highlight
ABSTRACT:
SUBMITTER: Nunez I
PROVIDER: S-EPMC5011436 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Nuñez Illyce I Rodriguez Pino Marbelys M Wiley David J DJ Das Maitreyi E ME Chen Chuan C Goshima Tetsuya T Kume Kazunori K Hirata Dai D Toda Takashi T Verde Fulvia F
eLife 20160730
RNA-binding proteins contribute to the formation of ribonucleoprotein (RNP) granules by phase transition, but regulatory mechanisms are not fully understood. Conserved fission yeast NDR (Nuclear Dbf2-Related) kinase Orb6 governs cell morphogenesis in part by spatially controlling Cdc42 GTPase. Here we describe a novel, independent function for Orb6 kinase in negatively regulating the recruitment of RNA-binding protein Sts5 into RNPs to promote polarized cell growth. We find that Orb6 kinase inhi ...[more]