Unknown

Dataset Information

0

Triptonide Effectively Inhibits Wnt/?-Catenin Signaling via C-terminal Transactivation Domain of ?-catenin.

ABSTRACT: Abnormal activation of canonical Wnt/?-catenin signaling is implicated in many diseases including cancer. As a result, therapeutic agents that disrupt this signaling pathway have been highly sought after. Triptonide is a key bioactive small molecule identified in a traditional Chinese medicine named Tripterygium wilfordii Hook F., and it has a broad spectrum of biological functions. Here we show that triptonide can effectively inhibit canonical Wnt/?-catenin signaling by targeting the downstream C-terminal transcription domain of ?-catenin or a nuclear component associated with ?-catenin. In addition, triptonide treatment robustly rescued the zebrafish "eyeless" phenotype induced by GSK-3? antagonist 6-bromoindirubin-30-oxime (BIO) for Wnt signaling activation during embryonic gastrulation. Finally, triptonide effectively induced apoptosis of Wnt-dependent cancer cells, supporting the therapeutic potential of triptonide.

SUBMITTER: Chinison J 

PROVIDER: S-EPMC5011721 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Triptonide Effectively Inhibits Wnt/β-Catenin Signaling via C-terminal Transactivation Domain of β-catenin.

Chinison Jessica J   Aguilar Jose S JS   Avalos Alan A   Huang Ying Y   Wang Zhijun Z   Cameron D Joshua DJ   Hao Jijun J  

Scientific reports 20160906

Abnormal activation of canonical Wnt/β-catenin signaling is implicated in many diseases including cancer. As a result, therapeutic agents that disrupt this signaling pathway have been highly sought after. Triptonide is a key bioactive small molecule identified in a traditional Chinese medicine named Tripterygium wilfordii Hook F., and it has a broad spectrum of biological functions. Here we show that triptonide can effectively inhibit canonical Wnt/β-catenin signaling by targeting the downstream  ...[more]

Similar Datasets

Unknown Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling.
| S-EPMC2722884 | biostudies-other
Unknown Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling.
| S-EPMC2431018 | biostudies-literature
Unknown Sevoflurane inhibits cholangiocarcinoma via Wnt/β-catenin signaling pathway.
| S-EPMC10422733 | biostudies-literature
Unknown Wnt-induced deubiquitination FoxM1 ensures nucleus β-catenin transactivation.
| S-EPMC4801947 | biostudies-literature
Unknown Fibulin-5 inhibits Wnt/β-catenin signaling in lung cancer.
| S-EPMC4558133 | biostudies-literature
Unknown Merlin inhibits Wnt/β-catenin signaling by blocking LRP6 phosphorylation.
| S-EPMC5041192 | biostudies-literature
Unknown PiRNA-63049 inhibits bone formation through Wnt/β-catenin signaling pathway.
| S-EPMC8579447 | biostudies-literature
Unknown USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin.
| S-EPMC6744515 | biostudies-literature
Unknown Adiponectin inhibits Wnt co-receptor, Lrp6, phosphorylation and β-catenin signaling.
| S-EPMC4747689 | biostudies-literature
Unknown Kctd15 inhibits neural crest formation by attenuating Wnt/beta-catenin signaling output.
| S-EPMC2926954 | biostudies-literature