Ontology highlight
ABSTRACT:
SUBMITTER: Wu W
PROVIDER: S-EPMC5011741 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Wu Wenting W Wagner Erin K EK Hao Yangyang Y Rao Xi X Dai Hongji H Han Jiali J Chen Jinhui J Storniolo Anna Maria V AMV Liu Yunlong Y He Chunyan C
Scientific reports 20160906
Inference of the biological roles of lncRNAs in breast cancer development remains a challenge. Here, we analyzed RNA-seq data in tumor and normal breast tissue samples from 18 breast cancer patients and 18 healthy controls and constructed a functional lncRNA-mRNA co-expression network. We revealed two distinctive co-expression patterns associated with breast cancer, reflecting different underlying regulatory mechanisms: (1) 516 pairs of lncRNA-mRNAs have differential co-expression pattern, in wh ...[more]