Ontology highlight
ABSTRACT:
SUBMITTER: van den Berg J
PROVIDER: S-EPMC5011748 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
van den Berg Jonas J Galbiati Heloisa H Rasmussen Akiko A Miller Samantha S Poolman Bert B
Scientific reports 20160906
Bacterial mechanosensitive channels protect cells from structural damage during hypoosmotic shock. MscS, MscL and MscK are the most abundant channels in E. coli and arguably the most important ones in osmoprotection. By combining physiological assays with quantitative photo-activated localization microscopy (qPALM), we find an almost linear relationship between channel abundance and cell survival. A minimum of 100 MscL (or MscS) channels is needed for protection when a single type of channel is ...[more]