Neuromagnetic oscillations predict evoked-response latency delays and core language deficits in autism spectrum disorders.

ABSTRACT: Previous studies have observed evoked response latency as well as gamma band superior temporal gyrus (STG) auditory abnormalities in individuals with autism spectrum disorders (ASD). A limitation of these studies is that associations between these two abnormalities, as well as the full extent of oscillatory phenomena in ASD in terms of frequency and time, have not been examined. Subjects were presented pure tones at 200, 300, 500, and 1,000 Hz while magnetoencephalography assessed activity in STG auditory areas in a sample of 105 children with ASD and 36 typically developing controls (TD). Findings revealed a profile such that auditory STG processes in ASD were characterized by pre-stimulus abnormalities across multiple frequencies, then early high-frequency abnormalities followed by low-f

SUBMITTER: Edgar JC 

PROVIDER: S-EPMC5012005 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature