Ontology highlight
ABSTRACT:
SUBMITTER: Schipper S
PROVIDER: S-EPMC5012145 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Schipper S S Aalbers M W MW Rijkers K K Swijsen A A Rigo J M JM Hoogland G G Vles J S H JS
Molecular neurobiology 20150926 8
Tonic GABAA receptors are a subpopulation of receptors that generate long-lasting inhibition and thereby control network excitability. In recent years, these receptors have been implicated in various neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, and epilepsy. Their distinct subunit composition and function, compared to phasic GABAA receptors, opens the possibility to specifically modulate network properties. In this review, the role of tonic GABAA receptor ...[more]