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Developing EZH2-Targeted Therapy for Lung Cancer.


ABSTRACT: Epigenetic targets are exciting new avenues for cancer drug discovery. Zhang and colleagues have designed the open-source EZH2 inhibitor JQEZ5 and shown antitumor efficacy in vitro and in vivo in preclinical studies in murine and human lung adenocarcinoma models expressing high levels of EZH2. Cancer Discov; 6(9); 949-52. ©2016 AACRSee related article by Zhang and colleagues, p. 1006.

SUBMITTER: Frankel AE 

PROVIDER: S-EPMC5012289 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Developing EZH2-Targeted Therapy for Lung Cancer.

Frankel Arthur E AE   Liu Xin X   Minna John D JD  

Cancer discovery 20160901 9


Epigenetic targets are exciting new avenues for cancer drug discovery. Zhang and colleagues have designed the open-source EZH2 inhibitor JQEZ5 and shown antitumor efficacy in vitro and in vivo in preclinical studies in murine and human lung adenocarcinoma models expressing high levels of EZH2. Cancer Discov; 6(9); 949-52. ©2016 AACRSee related article by Zhang and colleagues, p. 1006. ...[more]

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