Ontology highlight
ABSTRACT:
SUBMITTER: Cook DE
PROVIDER: S-EPMC5012401 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Cook Daniel E DE Zdraljevic Stefan S Tanny Robyn E RE Seo Beomseok B Riccardi David D DD Noble Luke M LM Rockman Matthew V MV Alkema Mark J MJ Braendle Christian C Kammenga Jan E JE Wang John J Kruglyak Leonid L Félix Marie-Anne MA Lee Junho J Andersen Erik C EC
Genetics 20160722 1
Telomeres are involved in the maintenance of chromosomes and the prevention of genome instability. Despite this central importance, significant variation in telomere length has been observed in a variety of organisms. The genetic determinants of telomere-length variation and their effects on organismal fitness are largely unexplored. Here, we describe natural variation in telomere length across the Caenorhabditis elegans species. We identify a large-effect variant that contributes to differences ...[more]