Ontology highlight
ABSTRACT:
SUBMITTER: Kleinschnitz C
PROVIDER: S-EPMC5012526 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Kleinschnitz Christoph C Mencl Stine S Kleikers Pamela W M PWM Schuhmann Michael K MK López Manuela G MG Casas Ana I AI Sürün Bilge B Reif Andreas A Schmidt Harald H H W HHHW
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20160628 9
Promising results have been reported in preclinical stroke target validation for pharmacological principles that disrupt the N-methyl-D-aspartate receptor-post-synaptic density protein-95-neuronal nitric oxide synthase complex. However, post-synaptic density protein-95 is also coupled to potentially neuroprotective mechanisms. As post-synaptic density protein-95 inhibitors may interfere with potentially neuroprotective mechanisms and sufficient validation has often been an issue in translating b ...[more]