Ontology highlight
ABSTRACT:
SUBMITTER: Santos da Silva E
PROVIDER: S-EPMC5012655 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Santos da Silva Eveline E Mulinge Martin M Lemaire Morgane M Masquelier Cécile C Beraud Cyprien C Rybicki Arkadiusz A Servais Jean-Yves JY Iserentant Gilles G Schmit Jean-Claude JC Seguin-Devaux Carole C Perez Bercoff Danielle D
PloS one 20160906 9
The cytoplasmic tail (gp41CT) of the HIV-1 envelope (Env) mediates Env incorporation into virions and regulates Env intracellular trafficking. Little is known about the functional impact of variability in this domain. To address this issue, we compared the replication of recombinant virus pairs carrying the full Env (Env viruses) or the Env ectodomain fused to the gp41CT of NL4.3 (EnvEC viruses) (12 subtype C and 10 subtype B pairs) in primary CD4+ T-cells and monocyte-derived-macrophages (MDMs) ...[more]