Ontology highlight
ABSTRACT:
SUBMITTER: Menazza S
PROVIDER: S-EPMC5012719 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Menazza Sara S Murphy Elizabeth E
Circulation research 20160107 6
Estrogen has important effects on cardiovascular function including regulation of vascular function, blood pressure, endothelial relaxation, and the development of hypertrophy and cardioprotection. However, the mechanisms by which estrogen mediates these effects are still poorly understood. As detailed in this review, estrogen can regulate transcription by binding to 2 nuclear receptors, ERα and ERβ, which differentially regulate gene transcription. ERα and ERβ regulation of gene transcription i ...[more]