Ontology highlight
ABSTRACT:
SUBMITTER: Mao YF
PROVIDER: S-EPMC5013027 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Mao Yan-Fang YF Guo Zhangyu Z Zheng Tingting T Jiang Yasi Y Yan Yaping Y Yin Xinzhen X Chen Yanxing Y Zhang Baorong B
Aging cell 20160726 5
Brain insulin signaling deficits contribute to multiple pathological features of Alzheimer's disease (AD). Although intranasal insulin has shown efficacy in patients with AD, the underlying mechanisms remain largely unillustrated. Here, we demonstrate that intranasal insulin improves cognitive deficits, ameliorates defective brain insulin signaling, and strongly reduces β-amyloid (Aβ) production and plaque formation after 6 weeks of treatment in 4.5-month-old APPswe/PS1dE9 (APP/PS1) mice. Furthe ...[more]