Ontology highlight
ABSTRACT:
SUBMITTER: Cua M
PROVIDER: S-EPMC5013266 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Cua Michelle M Wahl Daniel J DJ Zhao Yuan Y Lee Sujin S Bonora Stefano S Zawadzki Robert J RJ Jian Yifan Y Sarunic Marinko V MV
Scientific reports 20160907
Multiphoton microscopy enables imaging deep into scattering tissues. The efficient generation of non-linear optical effects is related to both the pulse duration (typically on the order of femtoseconds) and the size of the focused spot. Aberrations introduced by refractive index inhomogeneity in the sample distort the wavefront and enlarge the focal spot, which reduces the multiphoton signal. Traditional approaches to adaptive optics wavefront correction are not effective in thick or multi-layer ...[more]