Ontology highlight
ABSTRACT:
SUBMITTER: Bai XZ
PROVIDER: S-EPMC5013284 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Bai Xiao-Zhi XZ He Ting T Gao Jian-Xin JX Liu Yang Y Liu Jia-Qi JQ Han Shi-Chao SC Li Yan Y Shi Ji-Hong JH Han Jun-Tao JT Tao Ke K Xie Song-Tao ST Wang Hong-Tao HT Hu Da-Hai DH
Scientific reports 20160907
Acute kidney injury (AKI) is a common complication after severe burns. Melatonin has been reported to protect against multiple organ injuries by increasing the expression of SIRT1, a silent information regulator that regulates stress responses, inflammation, cellular senescence and apoptosis. This study aimed to investigate the protective effects of melatonin on renal tissues of burned rats and the role of SIRT1 involving the effects. Rat severely burned model was established, with or without th ...[more]