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Association between ABCB1 polymorphisms and haplotypes and Alzheimer's disease: a meta-analysis.

ABSTRACT: Although several epidemiological studies have investigated the association between ATP-binding cassette subfamily B member 1 (ABCB1) gene polymorphisms and Alzheimer's disease (AD) susceptibility, controversial results exist. Here, we performed a meta-analysis to assess whether ABCB1 polymorphisms 3435C?>?T (rs1045642), 2677G?>?T/A (rs2032582), 1236C?>?T (rs1128503) and haplotypes were associated with AD risk. Nine independent publications were included and analyzed. Crude odds ratio (OR) and 95% confidence interval (CI) were applied to investigate the strength of the association. Sensitivity analysis was conducted to measure the robustness of our analysis. A funnel plot and trim and fill method were used to test and adjust for publication bias. The results showed a significant association between the 3435C?>?T single nucleotide polymorphism (SNP) and AD susceptibility (CT vs. CC: OR?=?1.24, 95%?CI?=?1.06-1.45, P?=?0.01; CT?+?TT vs. CC: OR?=?1.21, 95%?CI?=?1.04-1.41, P?=?0.01) in the total population, as well as in Caucasian subgroup. The 2677G?>?T/A SNP was related to a decreased AD risk in Caucasian subgroup (TT?+?TA?+?AA vs. GT?+?GA?+?GG: OR?=?0.68, 95%?CI?=?0.47-0.98, P?=?0.04). Moreover, the ABCB1 haplotype analysis showed that the 1236T/2677T/3435C haplotype was associated with a higher risk of AD (OR?=?1.99, 95%?CI?=?1.24-3.18, P?=?0.00). Our results suggest that the ABCB1 3435C?>?T SNP, the 2677G?>?T/A SNP and 1236T/2677T/3435C haplotype are significantly associated with AD susceptibility.

SUBMITTER: Zhong X

PROVIDER: S-EPMC5013326 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Association between ABCB1 polymorphisms and haplotypes and Alzheimer's disease: a meta-analysis.

Zhong Xin X Liu Ming-Yan MY Sun Xiao-Hong XH Wei Min-Jie MJ

Scientific reports 20160907

Although several epidemiological studies have investigated the association between ATP-binding cassette subfamily B member 1 (ABCB1) gene polymorphisms and Alzheimer's disease (AD) susceptibility, controversial results exist. Here, we performed a meta-analysis to assess whether ABCB1 polymorphisms 3435C > T (rs1045642), 2677G > T/A (rs2032582), 1236C > T (rs1128503) and haplotypes were associated with AD risk. Nine independent publications were included and analyzed. Crude odds ratio (OR) and 95 ...[more]

PMID: 27600024

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Project description:IntroductionThe human multidrug resistance gene ATP-binding cassette B1 (ABCB1) codes for P-glycoprotein (P-gp), an important membrane-bound efflux transporter known to confer anticancer drug resistance as well as affect the pharmacokinetics of many drugs and xenobiotics. A number of single nucleotide polymorphisms (SNPs) have been identified throughout the ABCB1 gene that may have an effect on P-gp expression levels and function. Haplotype as well as genotype analysis of SNPs is becoming increasingly important in identifying genetic variants underlying susceptibility to human disease. Three SNPs, 1236C-->T, 2677G-->T and 3435C-->T, have been repeatedly shown to predict changes in the function of P-gp. The frequencies with which these polymorphisms exist in a population have also been shown to be ethnically related.MethodsIn this study, 95 individuals representative of the entire ethnic make-up of the USA were compared with 101 individuals from an Ashkenazi-Jewish population. These individuals were analyzed by genomic sequencing and polymerase chain reaction, using restriction fragment length polymorphisms, to calculate their genotype frequencies.ResultsA total of 25 SNPs were located in the exons of the ABCB1 gene. All of the polymorphisms identified were in parts of the ABCB1 gene product predicted to be intracellular, and 16 appear to be novel as compared with those listed by the National Center for Biotechnological Information. Frequencies of the 1236C-->T and 2677G-->T/A/C SNPs were similar for the US and Ashkenazi populations (64.2 and 60.4%, respectively for 1236C-->T [chi2: 0.30; p < or = 1]; 55.8 and 64.4%, respectively for 2677G-->T/A/C [chi2: 1.49; p < or = 1]), but were different for 3435C-->T (24.2% for the US population and 69.3% for the Ashkenazi population [chi2: 39.927; p < or = 0.001]). The 1236T/ 2677T/3435T haplotype occurred in 23.6% (standard error: 0.013) of the Ashkenazi population.ConclusionThe SNP at location 3435C-->T plays a significant role in the ABCB1 gene. The haplotype and genotype analysis from these data may be used as a basis for studies on the relationship between ABCB1 genotypes and drug efficacy, drug toxicity, disease susceptibility or other phenotypes.

Dataset Information

Association between ABCB1 polymorphisms and haplotypes and Alzheimer's disease: a meta-analysis.

Publications

Association between ABCB1 polymorphisms and haplotypes and Alzheimer's disease: a meta-analysis.

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