Ontology highlight
ABSTRACT:
SUBMITTER: Chitsazzadeh V
PROVIDER: S-EPMC5013636 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Nature communications 20160830
Cutaneous squamous cell carcinoma (cuSCC) comprises 15-20% of all skin cancers, accounting for over 700,000 cases in USA annually. Most cuSCC arise in association with a distinct precancerous lesion, the actinic keratosis (AK). To identify potential targets for molecularly targeted chemoprevention, here we perform integrated cross-species genomic analysis of cuSCC development through the preneoplastic AK stage using matched human samples and a solar ultraviolet radiation-driven Hairless mouse mo ...[more]