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Recent developments in HLA-haploidentical transplantations.

ABSTRACT: While allogeneic hematopoietic stem cell transplantations have a curative potential, several patients with hematologic malignancies cannot avail themselves of this therapeutic option due to lack of matched donor availability. Although HLA-haploidentical transplantations were previously associated with poor outcomes, recent evidence with use of post transplantation cyclophosphamide indicate improved safety and efficacy. The following paper discusses the most recent developments in this area.

SUBMITTER: Showel M 

PROVIDER: S-EPMC5013658 | biostudies-literature | 2015 Jun-Sep

REPOSITORIES: biostudies-literature

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Recent developments in HLA-haploidentical transplantations.

Showel Margaret M   Fuchs Ephraim J EJ  

Best practice & research. Clinical haematology 20150601 2-3

While allogeneic hematopoietic stem cell transplantations have a curative potential, several patients with hematologic malignancies cannot avail themselves of this therapeutic option due to lack of matched donor availability. Although HLA-haploidentical transplantations were previously associated with poor outcomes, recent evidence with use of post transplantation cyclophosphamide indicate improved safety and efficacy. The following paper discusses the most recent developments in this area. ...[more]

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