Ontology highlight
ABSTRACT:
SUBMITTER: Furniss RC
PROVIDER: S-EPMC5013874 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Furniss R Christopher D RC Slater Sabrina S Frankel Gad G Clements Abigail A
Journal of molecular biology 20160531 17
Enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC/EHEC) manipulate a plethora of host cell processes to establish infection of the gut mucosa. This manipulation is achieved via the injection of bacterial effector proteins into host cells using a Type III secretion system. We have previously reported that the conserved EHEC and EPEC effector EspG disrupts recycling endosome function, reducing cell surface levels of host receptors through accumulation of recycling cargo within the hos ...[more]