Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez P
PROVIDER: S-EPMC5014521 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Rodriguez Paloma P Pérez-Morgado M Isabel MI Gonzalez Víctor M VM Martín M Elena ME Nieto Amelia A
Molecular therapy. Nucleic acids 20160412
The genetic diversity of the influenza virus hinders the use of broad spectrum antiviral drugs and favors the appearance of resistant strains. Single-stranded DNA aptamers represent an innovative approach with potential application as antiviral compounds. The mRNAs of influenza virus possess a 5'cap structure and a 3'poly(A) tail that makes them structurally indistinguishable from cellular mRNAs. However, selective translation of viral mRNAs occurs in infected cells through a discriminatory mech ...[more]