Ontology highlight
ABSTRACT:
SUBMITTER: Cortez MA
PROVIDER: S-EPMC5014539 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Molecular therapy. Nucleic acids 20151215
MiR-34a, an important tumor-suppressing microRNA, is downregulated in several types of cancer; loss of its expression has been linked with unfavorable clinical outcomes in non-small-cell lung cancer (NSCLC), among others. MiR-34a represses several key oncogenic proteins, and a synthetic mimic of miR-34a is currently being tested in a cancer trial. However, little is known about the potential role of miR-34a in regulating DNA damage response and repair. Here, we demonstrate that miR-34a directly ...[more]